When your tablet must disintegrate within minutes — or even seconds — Sodium Starch Glycolate is the disintegrant of choice for the world’s leading formulators. NB Entrepreneurs manufactures pharmaceutical-grade SSG that delivers exceptional superdisintegrant performance with consistent swelling capacity, low sodium content, and multi-pharmacopoeial compliance. If rapid disintegration and fast dissolution are your formulation goals, SSG from NB Entrepreneurs will get you there.
Sodium Starch Glycolate (SSG) is a sodium salt of a carboxymethyl ether of starch, produced by cross-linking and substituting natural starch. It is classified as a superdisintegrant — a category of excipients that causes tablets to disintegrate rapidly upon contact with aqueous media. SSG works primarily through rapid, high-capacity water absorption (swelling up to 300 times its own volume), which creates internal pressure within the tablet matrix and causes rapid fragmentation. It is effective in both direct compression and granulated tablet formulations at concentrations as low as 2–8%.
SSG swells up to 300% of its original volume within seconds of water contact, delivering disintegration times far superior to conventional disintegrants.
Effective at 2–8% w/w — lower than many alternatives — reducing excipient costs and preserving tablet volume for active ingredients.
Effective in direct compression, wet granulation, and dry granulation formulations.
SSG’s disintegration performance is effective across the pH range of the gastrointestinal tract.
Low reactivity with APIs and other excipients, with good stability across temperature and humidity conditions.
Meets USP, BP, and IP monograph specifications.
| Parameters | USP – NF |
|---|---|
| Identification A, B, C, D | Complies |
| pH | |
| Type A | 5.5 – 7.5 |
| Type B | 3.0 – 5.0 |
| Loss on Drying, % | NMT 10 |
| Heavy Metals, ppm | NMT 20 # |
| Sodium Chloride, % | NMT 7 |
| Sodium Glycolate % | NMT 2 |
| Assay % | |
| Type A | 2.8 – 4.2 |
| Type B | 2.0 – 3.4 |
| Swelling Volume ml* | |
| Limit of Iron % | NMT 0.002 |
| Microbiology Limits | |
| Escherichia Coli | Absent in 1g Sample |
| Salmonella Species | Absent in a 10g Sample |
| Type | Size |
|---|---|
| HDPE Bags | 25 Kg |
| HDPE Bags | 20 Kg |
| Paper Bags | 25 Kg |
| Paper Bags | 20 Kg |
| FIBC | 400 Kg |
| Container | Palletized | Non-Palletized |
|---|---|---|
| 20 Ft. (Approx Wt.) | 10,000 Kg | 12,000 Kg |
| 40 Ft. (Approx Wt.) | 20,000 Kg | 24,000 Kg |
Rapid-release oral tablet formulations
Orally disintegrating tablets (ODT) and quick-dissolve formulations
Over-the-counter (OTC) analgesic, antacid, and cold remedy tablets
Generic drug tablet manufacturing requiring rapid dissolution
Direct compression and wet granulation tablet processes
Nutraceutical tablets requiring fast disintegration
With nearly five decades of manufacturing experience since 1976, cGMP-certified production facilities, and a track record serving 1,000+ customers across 192 cities and 20+ countries — including 75+ USFDA-accredited facilities — NB Entrepreneurs delivers Sodium Starch Glycolate (SSG) that meets the strictest pharmacopoeial standards. Our 18,000 MT/year MCC capacity ensures reliable bulk supply with 99.4% perfect order rate. Every batch ships with a full Certificate of Analysis, MSDS, and technical data sheet. Our dedicated technical team supports grade selection, formulation compatibility, and regulatory documentation — making us far more than just a supplier.
Sodium Starch Glycolate works primarily through rapid water absorption and swelling. When a tablet comes into contact with gastrointestinal fluid, SSG particles absorb water and swell to up to 300% of their original volume very rapidly. This swelling creates intense internal mechanical pressure within the tablet matrix, forcing it to fragment and disintegrate quickly — releasing the active ingredient for faster dissolution and absorption.
Sodium Starch Glycolate is typically used at concentrations of 2% to 8% w/w. The optimal level depends on the tablet’s API load, compaction pressure, and desired disintegration time. Higher concentrations (above 8%) may actually reduce performance due to gel formation that inhibits water penetration.
SSG is generally compatible with most APIs. However, as it is a sodium salt, it should be evaluated carefully with APIs sensitive to electrolytes. Compatibility studies are always recommended as part of standard pre-formulation work.