Alpha-lactose monohydrate and microcrystalline cellulose were co-spray-dried, creating a mono particulate system having two compaction mechanisms, brittle fracture and plastic deformation, within individual particles.

By combining both excipients, spray-drying was used in order to bring Lactose and Microcrystalline cellulose together. As a result a co-processed excipient was achieved that provides capability for direct compression, due to given Flowability and compactibility, making it suitable for both low dosage and high dosage formulations.

ADVANTAGES
  • Increased compactibility and powder flow
  • Improved Flowability and compaction properties
  • Improved content uniformity.
  • Increase tablet hardness
APPLICATIONS
  • Functional excipients used in oral solid dosage forms
  • May be used in dry granulation and capsule filling
  • Suitable for both Low dose and High dose formulations
UNIQUE FEATURES of SANCEL
  • A Hausner ratio below 1.25 or Carr’s index below 20 indicates that powders are freely flowing.
  • Excellent flow properties create the shear necessary to disperse API
  • Ideal for low-dose formulations where API content uniformity is critical.
  • Ideal tablet surface for straight forward and economical coating

Unique Features of SANCEL

  • Angle of Repose

  • Customized Bulk Density

  • Low Moisture

  • Excellent Flowability

  • Better Compressibility

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