Alpha-lactose monohydrate and microcrystalline cellulose were co-spray-dried, creating a mono particulate system having two compaction mechanisms, brittle fracture and plastic deformation, within individual particles.
By combining both excipients, spray-drying was used in order to bring Lactose and Microcrystalline cellulose together. As a result a co-processed excipient was achieved that provides capability for direct compression, due to given Flowability and compactibility, making it suitable for both low dosage and high dosage formulations.
ADVANTAGES
- Increased compactibility and powder flow
- Improved Flowability and compaction properties
- Improved content uniformity.
- Increase tablet hardness
APPLICATIONS
- Functional excipients used in oral solid dosage forms
- May be used in dry granulation and capsule filling
- Suitable for both Low dose and High dose formulations
UNIQUE FEATURES of SANCEL
- A Hausner ratio below 1.25 or Carr’s index below 20 indicates that powders are freely flowing.
- Excellent flow properties create the shear necessary to disperse API
- Ideal for low-dose formulations where API content uniformity is critical.
- Ideal tablet surface for straight forward and economical coating
Unique Features of SANCEL
Angle of Repose
Customized Bulk Density
Low Moisture
Excellent Flowability
Better Compressibility