Key Benefits & Why Formulators Choose NBE SANCEL® Silicified Microcrystalline Cellulose (SMCC)
Enhanced Flowability:
The colloidal SiO2 coating reduces inter-particle friction and cohesion, delivering better flow than standard MCC — especially critical for sticky or cohesive APIs.
Superior Compactibility:
SMCC demonstrates higher tensile strength tablets at equivalent compression forces compared to plain MCC, enabling harder tablets or reduced tablet weight.
Improved Lubrication Sensitivity:
SMCC maintains compactibility even in the presence of magnesium stearate, overcoming one of the biggest challenges in direct compression formulation.
Moisture Buffering:
The silicon dioxide component reduces moisture sensitivity, making SMCC ideal for moisture-sensitive active pharmaceutical ingredients.
Better API Distribution:
The uniform particle structure of SMCC promotes even API distribution throughout the tablet matrix.
Single-Step Advantage:
Replaces separate MCC + glidant additions, simplifying the formulation and reducing the number of excipients.
| Parameter | Value |
|---|---|
| Composition | MCC (~98%) + Colloidal Silicon Dioxide (~2% w/w) |
| CAS Number (MCC) | 9004-34-6 |
| CAS Number (CSD) | 7631-86-9 |
| Appearance | White to off-white, odourless, free-flowing powder |
| pH (10% slurry) | 5.0 – 7.5 |
| Loss on Drying | NMT 7.0% |
| Bulk Density | 0.28 – 0.38 g/mL |
| Pharmacopoeial Standards | USP-NF (as SMCC), BP, IP |
Frequently Asked Questions
What is silicified microcrystalline cellulose (SMCC)?
Silicified Microcrystalline Cellulose (SMCC) is a co-processed excipient made from approximately 98% MCC and 2% colloidal silicon dioxide.
How is SMCC different from a physical mixture of MCC and silicon dioxide?
SMCC is produced by co-processing MCC and colloidal SiO2 during manufacture, creating a uniform, intimate mixture at the particle level.
When should I use SMCC instead of standard MCC?
SMCC is the preferred choice when your API has poor flow properties or requires higher tablet tensile strength.
