Alpha-lactose monohydrate and microcrystalline cellulose were co-spray-dried, creating a mono particulate system having two compaction mechanisms, brittle fracture and plastic deformation, within individual particles.
By combining both excipients, spray-drying was used in order to bring Lactose and Microcrystalline cellulose together.
As a result a co-processed excipient was achieved that provides capability for direct compression, due to given Flowability and compactibility, making it suitable for both low dosage and high dosage formulations.
